Tamoxifen reviews Information for use :
Cancer of the snow chain ( especially in menopause); thoracic tumor chain (including in the stronger sex after castration); kidney swelling ; tumor and mesenchymal plastic materials , including estrogen sensors ; tumor ovarian tumor of the endometrium. Cancer of the prostate chain (the presence of resistance to other drugs).
Possible analogues ( substitutes ):
Vero Tamoxifen review ( to 35.00 rubles), Tamoxifen review hexane ( to 159.00 rubles), Bilem, allele -Tamoksifen, Zitazonium …
Show without exception analogues substances Tamoxifen review ”
Warning: the use of unique obligation to be agreed with the doctor’s doctor .
The active element , category :
Tamoxifen review (Tamoxifen review), Antitumor method , antiestrogen
dosage model :
- tablets, pills processed shell
- Hypersensitivity to Tamoxifen review, suyagnost , period of lactation caution . Diseases of the eye (including clouding ), hyperlipidemia, disease , thrombocytopenia, hypercalcemia, identified inflammation , thromboembolic disease (including a history of).
- The method of use and dose ( manual ):
- usually introduced individually into communication with evidence .
- Inside, the presence of snow chain cancers , kidneys – according to TWENTY – FORTY mg Tamoxifen review 1-2 once a period ( from morning and evening ), endometrium – TWENTY – THIRTY mg 1-2 once a period . In the direction – 2.4-9.6 g. Therapy with Tamoxifen review is performed continuously ( up to the onset of progression propertiesdiseases ), because the result is saved only in the background of continuous use ; the presence of need is used in a composition with radial and cytostatic therapy.
- Tamoxifen review tablets need to carry not liquid, squeezed small number of water in a single decision in the morning or by dividing the required dose in two ways , in the morning andin the evening .
Pharmacological effects :
Antitumor anti-estrogen method . Competitively inhibits estrogen sensors in target organs and tumors, committed with these organizations . As a result , an aggregate appears (the product is an interoreceptor , a transfer factor ), which , after translocation to the cellular base, prevents the hypertrophy of cells suitable for estrogen regulation .It has antigonadotropic qualities ; it is restrained by the combination of Pg in tumor matter . Delays the growth of tumor movement , urged by estrogen.
The ability to block estrogen is able to remain in a stretch of some months after one-time dose.
In addition to this , Tamoxifen review is able to produce ovulation in women the presence of its shortage ,boosting release from the hypothalamus of the GRF, which induces the release of the pituitary gonadotropic hormones. In the stronger sex with oligospermia it increases the concentration of LH and FSH, testosterone and estrogen in the serum monthly . Tamoxifen review and its specific metabolites (N-desmethylTamoxifen review, 4-hydroxy Tamoxifen review) are considered potent inhibitors of the hybrid function of the concept of liver cytochrome P450, but the medical role of these results has not been established..
Side effects :
- Ossalgiya, suffering in the sources of loss , an increase in body temperature ; reduction of hunger , vomiting , nausea , constipation, or diarrhea , in some cases – fatty liver leakage , cholestasis, illness ; overflow of skin with a sense of heat ; disease , anemia, coronary ,blockage , inflammation ; dermatological rash , dryish skin , increase the volume of soft tissue structures, in some cases accompanied by a manifest erythema slain zones and surrounding areas ( usually occurs in the stretch of 2 weeks); hypercalcemia, peripheral edema ( associated with the suspension of water ), alopecia , increased people torso ;depression , leading suffering , nausea , illness , high asthenia , lethargy , mental confusion ; loss of visual acuity, clouding of the cornea, clouding , retinopathy, optic disease . In girls , endometrial growth , reversible formation of cystic tumors, vaginal compartments , metrorrhagia, frustration , irritation
- sexual organizations , lack of .
- In men, there is a reduction in potency and / or attraction .
- Overdose with Tamoxifen review. Symptoms : increased secondary results .
- Treatment: symptomatic . A peculiar antidote is missing .
Special instructions Tamoxifen reviews:
Before the foundation of cure by Tamoxifen review, girls are obliged to make the way painstaking gynecological (rare case of pregnancy) and therapeutic research .
Tamoxifen review causes ovulation, which increases the risk of pregnancy, for this reason, girls of the reproductive year should use strong methods of contraception (non-hormonal) during the treatment period and for 3 months after the completion of treatment . In the period of therapy, it is necessary to monitor characteristics from time to time.
clotting monthly , concentration Ca2 + in monthly , view monthly (leucocytes, platelets), characteristic of liver function, Hellbourne , to implement inspection at the ophthalmologist – any 3 months, gynecological investigation ( the presence of occurrence of bleeding from the vagina or vaginal bleeding acceptance substance must stop ).
In patientswith metastases to the remains , from time to time during the initial stage of treatment it is necessary to establish the concentration of Ca2 + in serum menstruation (in the case of hypercalcemia manifested, taking Tamoxifen review should be temporarily stopped ). The presence of treatment of patients with metastases ( especially in the liver ) is ineffective .