The long-term direction of tamoxifen cost found himself successful five-year
twofold increase in the duration of the daily way of substance tamoxifen cost, with 5 up to 10 the year , reduces the degree of mortality and the threat of recurrence in women with estrogen-dependent on all fours snow chains , the characteristic features in the stretch further after the abolition of the substance of the decade.
These are the results of in-depth long-term study , the done the international team of scientists , in the structure of which joined experts from England , France, India, Argentina, Brazil, Egypt, Spain, Australia, Iran, countries China , Israel, Poland, Country , Italy, Czech Republic and Oman . The activity is published in The Lancet magazine .
Tamoxifen cost – against the ladies sexual hormone estrogen. Effect of substance is based in the possibility to associate with hormones sensors in the plane of the tumor cells and block their association with natural estrogen, suppressing this most impelling result , provided hormone in neoplasm . Tamoxifen cost is usually determined for premenopausal girls who have sustained an estrogen-dependent tumor. snow chain , with the aim of minimizing the notch of disease recurrence , and also staying in the team of the highest notch according to the disease in the property of prevention.
Previously previously existed confirmed , that that the effectiveness of tamoxifen cost increased according faces increasing duration of the process and the product began to install not in 2 years after the diagnosis, and in 5 , which reduced the mortality rate from the number of patients to a further one after stopping the method of a dozen . The latest study there due to examine the results still the most extended use of the substance .
In the medical testings , synitsiirovannyh more in 1996 city of about name” Tamoxifen cost: what is preferable – longer or in one word ?” (Adjuvant Tamoxifen cost: Longer Against Shorter ( ATLAS)), have taken to promote 12 894 girls from different states of society , in which there are existed diagnosed premature stage coffin snow chains , in 6846 with them – estrogen-dependent model of the disease . Approximately fifty percent of patients each day He took over tamoxifen cost in the stretch of 5 years , the other – in a stretch of 10 years .
It has been determined , the fact that long-term acceptance of the substance of the fairer sex with estrogen on all fours bust lowered from their threat of recurrence of the disease (617 recurrences in spite of 711 in the category of taking tamoxifen cost 5 years ), the degree of mortality from the main disease (331 deaths despite the 397 team of five ways ), and in addition a single degree of mortality (639 Konchin contrary 722 to the team of five ways ).
And, just as was , the most positive outcome with the most extended way of tamoxifen cost required in the future after the abolition of the substance of the year .Thus , the statistical possibility of recurrence command ten method in interval from 5th according to the ninth time with bases disease is 0.9, and then – 0.75; coefficient degree of mortality with the main disease – 0.97 spite 0.71.
As in this case, since the period of the creators of the show in the manifested a secondary result long-lasting method of tamoxifen cost – an increase in the notch coffin of the endometrium. Someone was opened at 3 % of girls who took the product to an extent 10 years , and only in 1.6 per cent of those , who just took him 5 years .
It should highlight , something that tamoxifen cost is considered a substance 1 direction only for the purpose ofpremenopausal patients. Estrogen-dependent girls on all fours of the snow chain in the position of menopause usually determine a different type of hormone therapy – the five-year direction of aromatase inhibitors, in some cases in combination with tamoxifen cost. Aromazine (exemestane), arimidex (anastrozole) and femara (letrazole) belong to aromatase inhibitors .